Playing devil's advocate so bear with me.If you think he'd run the same offense and defense, I don't know what to say. He'd adapt and do quite well.
Saban's teams have struggled mightily with spread teams with a mobile QB, much more so then would be expected with the amount of talent at their disposal.
I think you can discount ATM last year and this as transcendent QB play makes a lot of defenses look bad.
However, OU with Trevor Knight (as well as he played) is not a dominant offense with an experienced signal caller. Auburn has an amazing play caller but Nick Marshall is still pretty raw as a passer and was originally recruited to Georgia as a DB. I think some of the problem with the defense stems from the offensive style Alabama plays. Plodding power running and play action passing works great if you can force a couple of 3 and outs and then grind out some drives but it fails when you're behind.
BTW, for as much grief as Major gets, his gameplan versus OU with a gimpy armed QB was a lot better then Bama's. That OU dline is terrible and injured. Run at them and mix in vertical stretch. While I'm sure throwing bubble screens and watching Cooper run is run, doesn't do a whole lot to stretch the field and plays into OU's strength of primarily cover 2. Also, have they never heard of screen plays or draws?
Truly a baffling gameplan. For all his strengths, Saban got pretty badly outcoached. That is not a good OU team.
Hopefully he views this as a challenge and vows to wipe the smirk off Stoops face for years to come